SABCS2015冰冻手套可预防化疗
2016-8-31 来源：不详 浏览次数：次SABCS2015冰冻手套可预防化疗
[P]Frozenglovecouldbeanewhopeforpreventionofchemotherapyinducedperipheralneuropathy.
NakayamaT,YasojimaH,MorimotoT,YoshidomeK,MizutaniM,TakashimaT,MatsunamiN,EnamiA,KagawaM,NomuraT,ShibaE,NishiT,KamigakiS,KozumaY,YoshinamiT,MasudaN.
OsakaMedicalCenterforCancerandCardiovascularDisease,Osaka,Japan;NHOOsakaNationalHospital,Osaka,Japan;YaoMunicipalHospital,Yao,Osaka,Japan;OsakaPoliceHospital,Osaka,Japan;OsakaCityUniversityGraduateSchoolofMedicine,Osaka,Japan;OsakaRosaiHospital,Sakai,Osaka,Japan;OsakaBreastClinic,Osaka,Japan;KaizukaCityHospital,Kaizuka,Osaka,Japan;SakaiCityHospital,Sakai,Osaka,Japan;HigashiosakaCityGenaralHospital,Higashiosaka,Osaka,Japan.
Introduction:Chemotherapyinducedperipheralneuropathy(CIPN)isamajorproblemforpatientswhoreceivechemotherapy,nyCIPNpreventiontrialshavebeenconducted,butnoonesucceededtodate.
Objectives:Toinvestigateiffrozenglove(FG)preventsperipheralneuropathyinducedbynanoparticlealbumin-boundpaclitaxel(nab-PTX).
Methods:WeconductedCIPNpreventionstudyusingFG,aspartofmulti-institutionalphaseIIstudywhichanalyzeefficacyandsafetyofnab-PTX(mg/m2q3w)followedbyFEC(//mg/m2,q3w)inpre-operativesetting(KBCSG-TRtrial).EachpatientworeanFGsforatotalof60minutes(15minsbeforeandafternab-PTXtreatment)PNwereassessedduringtreatmentperiodwithnab-PTXbythePatientNeurotoxicityQuestionnaire(PNQ)andtheFACT/GOG(GynecologicOncologyGroup)Neurotoxicity(Ntx)tientswereaskedtoaccessPNQandFACT/GOGNtxonadailybasisandrecordedintheCIPNdiary.
Results:dfortytwopts(68%)dianageandmedianbodymassindex(BMI)was48yearsoldand21.6kg/m2,analyzedfollowing6categories,1)symptomsofhandsandarms,2)symptomsoffoots,3)symptomsofgeneral,4)symptomsofears5)muscleweaknessofhandsandarmsand6)diantimetoeacheventwas1)25.5days,2)5days,3)3days,4)notavailable,5)46.5days,6)usingFG,timetoeventofhandsandarmswasmuchlonger
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